Dimethylamine → 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-N,N-dimethyl-4-morpholin-4-yl-benzamide

HRID 32703Notes

Reaction equation

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=3[N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[C:21]([OH:23])=O)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:33])[CH:5]=1)(=[O:3])[CH3:2].[CH3:34][NH:35][CH3:36]>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:11][CH2:12][N:13]([C:16]([C:18]3[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=3[N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[C:21]([N:35]([CH3:36])[CH3:34])=[O:23])=[O:17])[CH2:14][CH2:15]2)=[C:6]([F:33])[CH:5]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 674Dimethylamine

HCID 59793575HCID 59793575, compound

Product 1

HCID 597936483-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-N,N-dimethyl-4-morpholin-4-yl-benzamide

Procedure

The title compound was prepared according to the procedure described for example K/step2 from 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-morpholin-4-yl-benzoic acid and dimethylamine (44%, yellow solid, MS (m/e): 483.2 (M+H, 100%)

Sources & evidence

ORD record: ord-4e3f9587338b4fb0a5600e303b935b18
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07427612B2

Reaction notes

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