2-Morpholin-4-yl-5-nitro-benzoyl chloride → 2-(4-(2-Morpholino-5-nitrobenzoyl)piperazin-1-yl)-5-(trifluoromethyl)benzonitrile

HRID 32707Notes

Reaction equation

HRID 32707 reaction equation
[N:1]1([C:7]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:8]=2[C:9]#[N:10])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[N:19]1([C:25]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][C:26]=2[C:27](Cl)=[O:28])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[N:19]1([C:25]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][C:26]=2[C:27]([N:4]2[CH2:5][CH2:6][N:1]([C:7]3[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:18])[F:17])=[CH:11][C:8]=3[C:9]#[N:10])[CH2:2][CH2:3]2)=[O:28])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 172741532-Morpholin-4-yl-5-nitro-benzoyl chlorideHCID 43153495HCID 43153495, compound

Product 1

HCID 111560472-(4-(2-Morpholino-5-nitrobenzoyl)piperazin-1-yl)-5-(trifluoromethyl)benzonitrile

Procedure

The title compound was prepared according to the procedure described for example 46 from 2-Piperazin-1-yl-5-trifluoromethyl-benzonitrile and 2-Morpholin-4-yl-5-nitro-benzoyl chloride (69%, yellow solid, MS (m/e): 490.2 (M+H, 100%)

Sources & evidence

ORD record
ord-6da82b54982a4ebea6cca2b673b81132
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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