HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → HCID 19378814, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-{[6-(2-Chloro-4-methoxyphenoxy)hexyl]thio}-4,5-dihydrothiazol-4-one | HCID 18921835 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 19378814 | HCID 19378814 | — |
Reaction Steps
Stir overnight at room temperature, 300 mg. of the iodide prepared in Examples 2 or 3, 3 ml. acetonitrile, 225 mg. 1,2,4-triazole and 274 mg. cesium carbonate in a reaction flask. Work up the reaction mixture in methylene chloride with a water wash and elute on a silica column with methylene chloride and ethylacetate to recover the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05272167 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-8eceeb48de5c45feb09950f11c2b236c |
| Source note | uspto-grants-1993_12 |