HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[1-(4-Chlorobenzyl)-3-(t-butylthio)-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid methyl ester → Quiflapon
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[1-(4-Chlorobenzyl)-3-(t-butylthio)-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid methyl ester | HCID 11762500 | — |
| Reactant | Methyl 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoate | HCID 15225389 | — |
| Product | Quiflapon | HCID 60923 | — |
Reaction Steps
Using the hydrolytic procedure of Step B but substituting the ester of Step D for the ester of Step A provided the title compound, which was recrystallized from 1:1 EtOAc/hexane. m.p. 208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05272145 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-a450aea2fb6d4df191b25dfd2ad48c2c |
| Source note | uspto-grants-1993_12 |