Morpholine → HCID 44580553, compound

HRID 32725Notes

Reaction equation

HRID 32725 reaction equation
Cl[C:2]1[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:20])[CH3:19])=[CH:14][C:13]=2[F:21])[CH2:8][CH2:7]1)=[O:5].[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[F:21][C:13]1[CH:14]=[C:15]([C:18](=[O:20])[CH3:19])[CH:16]=[CH:17][C:12]=1[N:9]1[CH2:10][CH2:11][N:6]([C:4](=[O:5])[C:3]2[CH:22]=[C:23]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:24]=[CH:25][C:2]=2[N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 597937161-{4-[4-(2-Chloro-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-phenyl}-ethanone

Product 1

HCID 44580553HCID 44580553, compound

Procedure

The title compound was prepared according to the procedure described for example 1 from 1-{4-[4-(2-Chloro-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-phenyl}-ethanone (example K) and morpholine (57%, white solid), MS (m/e): 490.2 (M+H, 100%)

Sources & evidence

ORD record
ord-f5c4fffb08ed44729dd18c980f806acc
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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