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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 327256Generated: October 26, 2026

Quiflapon → 3-[n-(4-Chlorobenzyl)-3-(1,1-dimethylethyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid

https://huagongshe.com/reaction/327256

Reaction equation

Participants

RoleNameHCIDCharge
ReactantQuiflaponHCID 60923—
ReactantMethyl 3-[N-(4-chlorobenzyl)-3-(1,1-dimethylethyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoateHCID 18947566—
Product3-[n-(4-Chlorobenzyl)-3-(1,1-dimethylethyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidHCID 18947537—

Reaction Steps

The title compound was prepared according to the conditions described in Step B of Example 1, but substituting the ester from Step B for the ester of Example 1. The title compound was recrystallized from EtOAc-EtOH; m.p. 201°-202° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05272145
Source datasetuspto-grants-1993_12
ORD IDord-4f90ddff6f9b4391b8c8513680f93568
Source noteuspto-grants-1993_12