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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 327261Generated: October 28, 2026

Propionyl chloride → 3-[N-(4-Chlorobenzyl)-3-propanoyl-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid

https://huagongshe.com/reaction/327261

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPropionyl chlorideHCID 62324—
ReactantMethyl 3-[N-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoateHCID 9892642—
Product3-[N-(4-Chlorobenzyl)-3-propanoyl-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidHCID 18947589—

Reaction Steps

The title compound was prepared according to the conditions described in Step B and Step C of Example 47, from methyl 3-[N-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate (prepared in Step A of Example 47), but using propanoyl chloride in place of trimethylacetyl chloride in Step B.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05272145
Source datasetuspto-grants-1993_12
ORD IDord-b4fe764ae45b47759df452ec5e953e4c
Source noteuspto-grants-1993_12