HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl vinyl ketone → 2-Methoxy-2-methyl-7-t-butyl-5-isopropyl-8-propyl-chroman-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl vinyl ketone | HCID 6570 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 2-Propyl-3-t-butyl-4-hydroxy-5-isopropylphenol | HCID 54017886 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methoxy-2-methyl-7-t-butyl-5-isopropyl-8-propyl-chroman-6-ol | HCID 54232336 | — |
Reaction Conditions
| Temperature | 3 °C |
|---|
Reaction Steps
Dissolve 2-propyl-3-t-butyl-4-hydroxy-5-isopropylphenol (2.0mol) and trimethyl orthoformate (0.3L) in methanol (1.2L) and degas. Place under a nitrogen atmosphere and cool to 3° C. and add concentrated sulfuric acid (5mL). Add, by dropwise addition, methyl vinyl ketone (340mL, 4.0mol) and stir without cooling for 44 hours. Pour into aqueous sodium hydrogen caronate and extract into ethyl ether. Dry (MgSO4) and evaporate the solvent in vacuo to give 2-methoxy-2-methyl-7-t-butyl-5-isopropyl-8-propyl-chroman-6-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05272252 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-5519d6f47db94e3cb941cb784bf96320 |
| Source note | uspto-grants-1993_12 |