HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → rel-(1S,2R)-1,2-bis(3'-Benzyloxy-4'-methoxyphenyl)-2-[(2",2"-dimethoxyethyl)-methyl-amino]ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2,2-Dimethoxyethylmethylamine | HCID 8503 | — |
| Reactant | rel-(S,S)-3,3'-dibenzyloxy-4,4'-dimethoxystilbene oxide | HCID 22849458 | — |
| Solvent | (+-)-2-Butanol | HCID 6568 | — |
| Product | rel-(1S,2R)-1,2-bis(3'-Benzyloxy-4'-methoxyphenyl)-2-[(2",2"-dimethoxyethyl)-methyl-amino]ethanol | HCID 11813953 | — |
Reaction Steps
Mixture: 51.7 g (0.11 mol) of rel-(S,S)-3,3'-dibenzyloxy-4,4'-dimethoxystilbene oxide, 1800 ml of dichloromethane, 100 ml of 2-butanol, 25 ml (0.19 mol) of methylaminoacetaldehyde dimethyl acetal, 5 g of silica gel
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05272270 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-b3004aa37dd04692baa37e139de32f93 |
| Source note | uspto-grants-1993_12 |