Ammonia → rel-(1S,2R)-1,2-bis(3'-Benzyloxy-4'-methoxyphenyl)-2-aminoethanol

HRID 327337Notes

Reaction equation

HRID 327337 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C@@H:17]2[O:35][C@H:18]2[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH:20]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:36]>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C@H:17]([OH:35])[C@@H:18]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH:20]=2)[NH2:36])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22849458rel-(S,S)-3,3'-dibenzyloxy-4,4'-dimethoxystilbene oxide

Product 1

HCID 22849455rel-(1S,2R)-1,2-bis(3'-Benzyloxy-4'-methoxyphenyl)-2-aminoethanol

Procedure

Mixture: 1.0 g (2.1 mmol) of rel-(S,S)-3,3'-dibenzyloxy-4,4'-dimethoxystilbene oxide, 15 ml of EtoH, abs., 15 ml of ammonia.

Sources & evidence

ORD record
ord-77c22dbf596b4b4f8c1b7190c060ed3c
Source dataset
uspto-grants-1993_12
Patent number
US05272270

Reaction notes

Loading…