HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → Maleimidoacetic acid N-hydroxysuccinimide ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Reactant | 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid | HCID 319935 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | Maleimidoacetic acid N-hydroxysuccinimide ester | HCID 3299229 | 99.1% |
Reaction Steps
Maleimidoacetic acid (155 mg, 1.0 mmol) in 5 ml of diglyme was treated at 0° C. with N-hydroxysuccinimide (127 mg, 1.1 mmol) and dicyclohexylcarbodiimide (227 mg, 1.1 mmol). After 1 hour at 0° C. and 3 hours at room temperature, the reaction mixture was filtered and evaporated to dryness to yield 0.25 g of crude maleimidoacetic acid N-succinimidyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273743 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-af1dc5f34405494aaf454788d0f1a090 |
| Source note | uspto-grants-1993_12 |