HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 1-(Difluoro-phenyl)-4-(p-propylphenyl)-cyclohex-1-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 1,2-Difluorobenzene | HCID 9706 | — |
| Reactant | 4-(4-Propylphenyl)cyclohexan-1-one | HCID 14495754 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 1-(Difluoro-phenyl)-4-(p-propylphenyl)-cyclohex-1-ene | HCID 14495755 | — |
Reaction Steps
To a mixture of 1,2-difluorobenzene (0.1 mol) and 100 ml THF a mixture of n-butyllithium (0.105 ml) and 60 ml hexane is added at -70° C. After stirring for 6 h a mixture of 4-(p-propylphenyl)-cyclohexanone (0.1 mol) and 50 ml THF is added. After stirring for 2 h, warming to room temperatures, boiling with PTSA as described for 10A and usual work-up 1-(difluoro-phenyl)-4-(p-propylphenyl)-cyclohex-1-ene is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273680 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-e9d051bfb0a749899c6bce1c3096fc52 |
| Source note | uspto-grants-1993_12 |