HCID 86747426, compound → HCID 19108409, compound

Participants

Reaction Steps

A solution of 2-(dimethylaminomethyl)-1-azabicyclo[2.2.2]octan-3-one oxime (3.55 g, 18 mmoles) in reagent grade ethanol (150 ml) was treated with Raney Nickel and hydrogenated in a Parr apparatus at room temperature and 55-58 psi for 18 hours. The product solution was filtered through Celite®, concentrated in vacuo, and subjected to bulb-to-bulb distillation (bp 100°-120° C. at 0.30 mm Hg) to provide 2.57 g (78%) of a colorless oil. The product was shown to be a mixture of cis:trans (1:3) isomers by nmr and glc analysis.

Provenance & Evidence