HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Chloro-2-methoxy-4-(methylamino)phenyl)(1H-imidazol-1-yl)methanone → 2-(1-Piperidinylmethyl)-1-azabicyclo[2.2.2]oct-3-yl 5-chloro-2-methoxy-4-(methylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Chloro-2-methoxy-4-(methylamino)phenyl)(1H-imidazol-1-yl)methanone | HCID 13492556 | — |
| Reactant | 2-(1-Piperidinylmethyl)-1-azabicyclo[2.2.2]octan-3-ol | HCID 19108399 | — |
| Reactant | HCID 178418244 | HCID 178418244 | — |
| Product | 2-(1-Piperidinylmethyl)-1-azabicyclo[2.2.2]oct-3-yl 5-chloro-2-methoxy-4-(methylamino)benzoate | HCID 53768000 | — |
Reaction Steps
2-(1-Piperidinylmethyl)-1-azabicyclo[2.2.2]octan-3-ol cis isomer (2.47 g, 11 mmoles) was treated with n-butyllithium/hexane, and then with 1-[5-chloro-2-methoxy-4-(methylamino)benzoyl]-1H-imidazole, following the procedures described above for the corresponding trans isomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273972 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-62da3d49246142ad9d00047d7a4af0ad |
| Source note | uspto-grants-1993_12 |