Diethyl Ether → HCID 19108457, compound

Participants

Reaction Steps

Using 1.8 g of the compound obtained in Example 5, the procedure of Example 2 was followed to give 1.82 g of the free base of the title compound mixture A and B. The first crop of crystals (0.65 g) from a solution of this mixture in diethyl ether, i.e. 7-[1-oxo-3-[1-(phenylmethyl)piperidin-4-yl]-propyl]-1,2,3,4-tetrahydroquinoline (m.p. 132°-135° C.), was treated with an equivalent of fumaric acid to give 0.69 g of the title fumarate (B) as colorless crystals melting at 175° to 177° C. (decomp.).

Provenance & Evidence