Hydrochloric Acid → HCID 9873179, compound

Participants

Reaction Steps

The compound from Step 1 (174 mg) was dissolved in THF (5 mL), MeOH (3 mL), 1N LiOH (1.3 mL) and heated at 65° C. for 1 hr. After cooling to r.t., the mixture was acidified with 1N HCl and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, filtered, and evaporated to dryness. The residue was purified by silica gel chromatography eluting first with 1:1 EtOAc/hexane and followed by the addition of 5% HOAc to this solvent. The title compound (126 mg), was obtained as a white solid; mp 227.5°-228.5° C.

Provenance & Evidence