Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-5-(methylsulphonyl)benzoic acid → Rac-2-(3-hydroxymethyl-pyrrolidin-1-yl)-5-methanesulfonyl-benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-5-(methylsulphonyl)benzoic acid | HCID 2329132 | — |
| 반응물 | (Pyrrolidin-3-yl)methanol | HCID 13400657 | — |
| 반응물 | 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid | HCID 59793489 | — |
| 생성물 | Rac-2-(3-hydroxymethyl-pyrrolidin-1-yl)-5-methanesulfonyl-benzoic acid | HCID 59793550 | 39% |
반응 단계
The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example Y) from 2-Chloro-5-methanesulfonyl-benzoic acid and rac-pyrrolidin-3-yl-methanol and obtained in 39% yield. MS (m/e): 298.1 (M−H, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427612B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-d5080999366c46b5b42605764bfd43cc |
| 출처 메모 | uspto-grants-2008_09 |