HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 1-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-Methyl-4-nitro-1H-imidazole-2-carboxylic acid | HCID 12067998 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride | HCID 19108629 | — |
Reaction Steps
To a solution of 1-methyl-4-nitroimidazole-2-carboxylic acid (2.0 g, 0.012 mol) in dry THF (20 mL) was slowly added oxalyl chloride (6 mL). The solution was heated to reflux for 45 minutes, and the solvent and excess oxalyl chloride were removed under reduced pressure to give 1-methyl-4-nitroimidazole-2-carbonyl chloride as a yellow powder which was coevaporated with dry CH2Cl2 (15 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273991 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-d05f0e15c49f4f5eaa690a306ce1426a |
| Source note | uspto-grants-1993_12 |