2-Methyl-2-thiopseudourea sulfate → HCID 178512752, compound

HRID 327489Notes

Reaction equation

HRID 327489 reaction equation
[NH2:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:4]=1.S(O)(O)(=O)=O.CS[C:20](=[NH:22])[NH2:21]>[OH-].[Na+]>[NH:1]([CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:4]=1)[C:20]([NH2:22])=[NH:21]

Participants

4

Reactant 2

HCID 752702-Methyl-2-thiopseudourea sulfateHCID 19108613HCID 19108613, compound

Product 1

HCID 178512752HCID 178512752, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

6.8 g (0.04 mol) of the product from Example 12 are dissolved in 40 ml of 1 N sodium hydroxide solution and 5.56 g of S-methylisothiourea hydrogen sulfate (=0.04 mol of urea) in solid form are added. The mixture is stirred at room temperature for 24 hours, during which the product slowly crystallizes out, and is filtered off with suction and washed thoroughly with water. Yield: 2.8 g; melting point >297° C.

Workup

  1. customslowly crystallizes out
  2. filtrationis filtered off with suction
  3. washwashed thoroughly with water

Sources & evidence

ORD record
ord-56931c544e1945d1ad223510db30ad86
Source dataset
uspto-grants-1993_12
Patent number
US05273989

Reaction notes

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