HCID 13921016, compound → HCID 19108583, compound

HRID 327490Notes

Reaction equation

HRID 327490 reaction equation
[N+:1]([CH2:4][CH2:5][CH2:6][C:7]([O:9]C(C)(C)C)=[O:8])([O-:3])=O.C(OC([CH:21]=[CH:22][CH2:23][NH2:24])=O)(C)(C)C>CC(C)=O>[NH2:24][CH2:23][CH:22]1[O:3][N:1]=[C:4]([CH2:5][CH2:6][C:7]([OH:9])=[O:8])[CH2:21]1

Participants

4

Reactant 2

HCID 13921016HCID 13921016, compoundHCID 86738925HCID 86738925, compound

Product 1

HCID 19108583HCID 19108583, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The racemic product is prepared starting from tert.-butyl 4-nitrobutyrate and N-tert.-butoxycarbonylallylamine in analogy to Example 12. After cleavage of the protecting groups, it is taken up in acetone and the betaine is precipitated by adjusting the pH to 6 by means of conc. aq. ammonia. The melting point is 201° C. (with dec.).

Workup

  1. customThe racemic product is prepared
  2. customthe betaine is precipitated

Sources & evidence

ORD record
ord-352d0c0951424870b52b31a7a37149b3
Source dataset
uspto-grants-1993_12
Patent number
US05273989

Reaction notes

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