HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → N-[4-(1-t-butoxyformamido)butyryl]-beta-alanine benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 4-(((Tert-butoxy)carbonyl)amino)butanoic acid | HCID 294894 | — |
| Reactant | Chloro-dimethoxy-triazine | HCID 12493616 | — |
| Reactant | 4-Methylbenzene-1-sulfonic acid--benzyl beta-alaninate (1/1) | HCID 13502100 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-(1-t-butoxyformamido)butyryl]-beta-alanine benzyl ester | HCID 19926286 | — |
Reaction Steps
4-(t-Butoxycarbonylamino)butyric acid in THF was activated with chlorodimethoxytriazine and N-methylmorpholine and reacted with β-alanine benzyl ester p-toluenesulphonate in the presence of N-methylmorpholine to give N-[4-(1-t-butoxyformamido)butyryl]-β-alanine benzyl ester, m.p. 54°-55° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273982 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-6b91b2e342c84db5ba17df2855251161 |
| Source note | uspto-grants-1993_12 |