Benzyl 3-phenyl-L-alaninate → HCID 10437796, compound

HRID 327513Notes

Reaction equation

HRID 327513 reaction equation
[CH2:1]([O:8][C:9](=[O:23])[CH2:10][C@@H:11]([C:20]([OH:22])=O)[NH:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:24]([O:31][C:32](=[O:42])[C@H:33]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[NH2:34])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:24]([O:31][C:32](=[O:42])[C@H:33]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[NH:34][C:20](=[O:22])[C@H:11]([CH2:10][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:23])[NH:12][C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 736312Benzyl 3-phenyl-L-alaninateHCID 1581888N-tert-Butoxycarbonyl-L-aspartic acid beta-benzyl ester

Product 1

HCID 10437796HCID 10437796, compound

Procedure

N-(t-butoxycarbonyl)-L-aspartic acid 4-benzyl ester was coupled with 3-phenyl-L-alanine benzyl ester to give N-[3-[(benzyloxy)carbonyl]-N-(t-butoxycarbonyl)-L-alanyl]-3-phenyl-L-alanine benzyl ester, m.p. 93°-94° C.

Sources & evidence

ORD record
ord-ec644a0ef75742a987eb3801fa4b5d10
Source dataset
uspto-grants-1993_12
Patent number
US05273982

Reaction notes

Loading…