HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyanopyridine-2-carboxylic acid → N-[3-[(benzyloxy)carbonyl]-N-[N-[(5-cyano-2-pyridyl)carbonyl]-beta-alanyl]-L-alanyl]-3-phenyl-L-alanine benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyanopyridine-2-carboxylic acid | HCID 12400734 | — |
| Reactant | 3-[(Benzyloxy)carbonyl]-N-[N-[N-(t-butoxycarbonyl)-beta-alanyl]-L-alanyl]-3-phenyl-L-alanine benzyl ester | HCID 86747431 | — |
| Product | N-[3-[(benzyloxy)carbonyl]-N-[N-[(5-cyano-2-pyridyl)carbonyl]-beta-alanyl]-L-alanyl]-3-phenyl-L-alanine benzyl ester | HCID 54354798 | — |
Reaction Steps
N-[3-[(Benzyloxy)carbonyl]-N-[N-[N-(t-butoxycarbonyl)-β-alanyl]-L-alanyl]-3-phenyl-L-alanine benzyl ester was deprotected and coupled with 5-cyano-2-pyridinecarboxylic acid to give N-[3-[(benzyloxy)carbonyl]-N-[N-[(5-cyano-2-pyridyl)carbonyl]-β-alanyl]-L-alanyl]-3-phenyl-L-alanine benzyl ester, m.p. 157°-158° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273982 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-a187abe51e284f87ad3785fd424cd50a |
| Source note | uspto-grants-1993_12 |