HCID 3041597, compound → HCID 18966567, compound

HRID 327538Notes

Reaction equation

HRID 327538 reaction equation
N[CH:2]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8](OC)[CH:9]=2)[O:4][CH2:3]1.NC1[CH2:24][C:23]2[C:18](=CC(OC)=C[CH:22]=2)[O:17]C1.[NH2:27][CH:28]1[CH2:37][C:36]2C(=C(OC)C=CC=2)OC1.[NH2:40][CH:41]1CC2C(OC)=CC=CC=2S[CH2:42]1.NC1CC2C=[C:61]([O:64]C)C=CC=2SC1>>[CH2:28]([N:27]([CH2:42][CH2:41][NH:40][C:18](=[O:17])[CH:23]([CH3:22])[CH3:24])[CH:3]1[CH2:2][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:64][CH3:61])[O:4]1)[CH2:37][CH3:36]

Participants

6

Reactant 5

HCID 3041597HCID 3041597, compoundHCID 30416017-methoxychroman-3-amine2×HCID 139289388-Methoxy-3,4-dihydro-2H-1-benzopyran-3-amine2×HCID 143304585-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amineHCID 219154716-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

Product 1

HCID 18966567HCID 18966567, compound

Procedure

By replacing 3-amino-5-methoxychroman in the above examples by 3-amino-6-methoxychroman, 3-amino-7-methoxychroman or 3-amino-8-methoxychroman, respectively, or by replacing 3-amino-5-methoxy-3,4-dihydro-2H-1-benzothiopyran by 3-amino-6-methoxy-3,4-dihydro-2H-1-benzothiopyran, by 3-amino-7-methoxychroman or 3-amino-8-methoxychroman, the isomers of Examples Nos. 1 to 56 methoxylated at 6-, 7- or 8-position, respectively, are obtained.

Workup

  1. customrespectively, are obtained

Sources & evidence

ORD record
ord-e4e175e31a2041c5b855245fef68b74a
Source dataset
uspto-grants-1993_12
Patent number
US05273994

Reaction notes

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