HuagongsheHuagongshe Chemistry Print Report · For research reference only
Homophthalic anhydride → 2-({3-[(E)-2-(4-Isopropyl-thiazol-2-yl)-vinyl]-phenylcarbamoyl}-methyl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Homophthalic anhydride | HCID 12801 | — |
| Reactant | 4-Isopropyl-2-(trans-3-aminostyryl) thiazole | HCID 14051165 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-({3-[(E)-2-(4-Isopropyl-thiazol-2-yl)-vinyl]-phenylcarbamoyl}-methyl)-benzoic acid | HCID 9844251 | 85.2% |
Reaction Steps
A mixture of 1.2 g of (E)-3-[2-[4-(1-methylethyl)-2-thiazolyl]ethenyl]benzeneamine, 0.8 g of homophthalic anhydride and 25 ml of toluene was heated to reflux for 0.5 hr. Upon cooling to room temperature, the solid reaction product was filtered and washed with ethyl ether to yield 1.7 g of (E)-2-[2-[3-[2-[4-(1-methylethyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid. Recrystallization from ethyl alcohol yielded off-white solid material; m.p. 203°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273986 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-8d03b41a1581486ab8b8edb1afc61a2d |
| Source note | uspto-grants-1993_12 |