HRID327550

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12801

Homophthalic acid anhydride

C9H6O3

HCID15136082

未命名化合物

PRODUCTS

生成物

结构：O=C(Cc1ccccc1C(=O)O)Nc1cccc(/C=C/c2nc(C3CCCC3)cs2)c1

HCID20084332

未命名化合物

收率 86.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A solution of 2.7 g of (E)-3-[2-[4-(cyclopentyl)-2-thiazolyl]ethenyl]benzeneamine, 1.78 g of homophthalic anhydride and 40 ml of toluene was heated to reflux for 0.5 hr. Cooling and filtration yielded 3.75 g of (E)-2-[2-[3-[2-[4-(cyclopentyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 209°-210° C. from tetrahydrofuran.

WORKUP

后处理

temperatureto reflux for 0.5 hr
temperatureCooling
filtrationfiltration