HuagongsheHuagongshe Chemistry Print Report · For research reference only
Homophthalic anhydride → (E)-2-[2-[3-[2-[4-(cycloheptyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Homophthalic anhydride | HCID 12801 | — |
| Reactant | (E)-3-[2-[4-(cycloheptyl)-2-thiazolyl]ethenyl]benzeneamine | HCID 20084328 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-2-[2-[3-[2-[4-(cycloheptyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid | HCID 20084350 | 71.3% |
Reaction Steps
A solution of 2.1 g of (E)-3-[2-[4-(cycloheptyl)-2-thiazolyl]ethenyl]benzeneamine, 1.25 g of homophthalic anhydride and 30 ml of toluene was heated to reflux for 0.5 hr. Cooling and filtration yielded 2.31 g of (E)-2-[2-[3-[2-[4-(cycloheptyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 189°-190° C. from tetrahydrofuran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273986 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-812012607a6c48489e529ef1f2a5960e |
| Source note | uspto-grants-1993_12 |