反应详情

A solution of 4.5 g of 2-carboethoxy-4-(1-methylethyl)thiazole, 100 ml of ethyl alcohol and 1.1 g of sodium borohydride was heated to reflux for 4 hr. The reaction mixture was then condensed to one half of the original volume in vacuo, diluted with 150 ml of water and extracted with methylene chloride. The combined extracts were washed with water, dried (MgSO4) and condensed in vacuo to give 4.0 g of 4-(1-methylethyl)-2-thiazole methanol; m.p. 80°-82° C.

1. temperatureto reflux for 4 hr
2. customcondensed to one half of the original volume in vacuo
3. extractionextracted with methylene chloride
4. washThe combined extracts were washed with water
5. customdried
6. custom(MgSO4) and condensed in vacuo