HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydropyran → (E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydropyran | HCID 8894 | — |
| Reactant | Homophthalic anhydride | HCID 12801 | — |
| Reactant | (E)-2-[2-(3-aminophenyl)ethenyl]-4-thiazolecarboxylic acid ethyl ester | HCID 14051204 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid | HCID 20084377 | 100.6% |
Reaction Steps
A solution of 0.5 g of (E)-2-[2-(3-aminophenyl)ethenyl]-4-thiazolecarboxylic acid ethyl ester, 0.3 g of homophthalic anhydride, 15 ml of toluene and 5 ml of tetrahydropyran was heated to reflux for 0.5 hr. Upon cooling, a solid formed which was filtered to yield 0.8 g of (E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 221°-223° C. from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273986 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-287b1a368abe4273a1e9b79c8ed2fcfd |
| Source note | uspto-grants-1993_12 |