HuagongsheHuagongshe Chemistry Print Report · For research reference only
Homophthalic anhydride → (E)-2-[2-[3-[2-(2-cyclobutyl-4-thiazolyl)ethenyl]phenylamino]-2-oxoethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Homophthalic anhydride | HCID 12801 | — |
| Reactant | (E)-3-[2-[2-Cyclobutyl-4-thiazolyl]ethenyl]phenylamine | HCID 20084338 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (E)-2-[2-[3-[2-(2-cyclobutyl-4-thiazolyl)ethenyl]phenylamino]-2-oxoethyl]benzoic acid | HCID 20084324 | 47.1% |
Reaction Steps
A mixture of 0.13 g of (E)-3-[2-[2-cyclobutyl-4-thiazolyl]ethenyl]phenylamine, 0.094 g of homophthalic anhydride and 10 ml of toluene was heated on a steam bath for 1 hr and then allowed to cool to room temperature. Filtration of the reaction mixture yielded 0.1 g of (E)-2-[2-[3-[2-(2-cyclobutyl-4-thiazolyl)ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 198°-199° C. from acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273986 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-a8f37bb93e914dfd9b8693108ecefaa2 |
| Source note | uspto-grants-1993_12 |