HCID 12436397, compound → (E)-5-acetoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid

Participants

Role	Name	HCID	Charge
Reactant	HCID 12436397	HCID 12436397	—
Reactant	(E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine	HCID 15136086	—
Solvent	Toluene	HCID 1140	—
Product	(E)-5-acetoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid	HCID 20084344	148.2%

Reaction Steps

A mixture composed of 0.58 g of (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine, 0.48 g of 5-acetoxyhomophthalic anhydride and 50 ml of toluene was heated on a steam bath for 0.5 hr. The mixture was cooled and the solids that formed were isolated by filtration to yield 0.77 g of (E)-5-acetoxy-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 176°-179° C. after trituration with hot acetonitrile.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05273986
Source dataset	uspto-grants-1993_12
ORD ID	ord-0a06943cd11547c48555d45bd6d5995b
Source note	uspto-grants-1993_12