Ammonium Hydroxide → HCID 18655859, compound

Participants

Reaction Steps

The product of Example 35 and excess pyridine hydrochloride were heated in an oil bath at 200° C. for 1 hr. The reaction was cooled, diluted with H2O, basified with NH4OH and extracted with ether. The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was subjected to flash chromatography (Silica: 6:4 pet I0 ether/EtOAc) and the product [upper isomer by TLC (Silica: 1:1 pet ether/EtOAc) showed characteristic peaks at: NMR (300 MHz, CDCl3) δ 7.9-6.6(m, 7H), 5.7(dd, 1H), 0.9(t, 3H).

Provenance & Evidence