反应详情

To a stirring solution of 0.8 g (2.9 mmol) of methyl 3-(3-cyclopentoxy-4-methoxyphenyl)-E-propenoate in 20 mL of methanol was added dropwise 25 mL of a 1.0N solution of potassium hydroxide in water over a 5 minute period. The mixture precipitated immediately, but returned to a solution after a 16-hour period at which time the solution was concentrated, diluted with 20 mL of water and neutralized to pH 1.0 with concentrated hydrochloric acid. The analytically pure white solid which formed was collected, washed several times with cold water, and dried in vacuo.

1. customThe mixture precipitated immediately
2. waitreturned to a solution after a 16-hour period at which time
3. concentrationthe solution was concentrated
4. additiondiluted with 20 mL of water and neutralized to pH 1.0 with concentrated hydrochloric acid
5. customThe analytically pure white solid which formed
6. customwas collected
7. washwashed several times with cold water
8. customdried in vacuo