HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroethanol → 2-(Pyridin-3-yloxy)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroethanol | HCID 34 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-Hydroxypyridine | HCID 7971 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-(Pyridin-3-yloxy)ethan-1-ol | HCID 21908997 | 23.5% |
Reaction Steps
This compound was prepared according to the procedure in Preparation 19. Thus, reacting 14 g (0.15 mole) of 3-hydroxypyridine with 27 ml (0.4 mole) of 2-chlorethanol and 85 g of potassium carbonate in 150 ml of 2-butanone at reflux temperature gave 4.9 g of the title compound after column chromatography (5% methanol in methylene chloride on silica gel).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273993 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-a22fdac463c048c392bbb8848950d6a8 |
| Source note | uspto-grants-1993_12 |