3-Bromoanisole → 3-(4-Phenyl-1H-imidazol-1-yl)phenol

HRID 327638Notes

Reaction equation

HRID 327638 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]([OH:12])[CH:9]=[CH:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[C:13]1(C2N=CNC=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.BrC1C=C(OC)C=CC=1>>[C:13]1([C:4]2[N:3]=[CH:2][N:1]([C:6]3[CH:7]=[C:8]([OH:12])[CH:9]=[CH:10][CH:11]=3)[CH:5]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 3

HCID 169713-BromoanisoleHCID 104645913-(1H-Imidazol-1-yl)phenolHCID 178418822HCID 178418822, compound

Product 1

HCID 127184433-(4-Phenyl-1H-imidazol-1-yl)phenolYield 57%

Procedure

Following the procedure for preparation of 3-(1H-imidazol-1-yl) phenol (preparation 29), 4-phenylimidazole (20 g, 0.138 mole) and 3-bromoanisole (32 ml, 0.25 mole) were reacted to give the title compound in 57% yield; mp 195°-197° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-5d1495c4bf594ac0a8f50f2cda47a1f9
Source dataset
uspto-grants-1993_12
Patent number
US05273993

Reaction notes

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