Chlorosulfamic acid → HCID 19108662, compound

HRID 327683Notes

Reaction equation

HRID 327683 reaction equation
[S:1](Cl)(=[O:4])(=[O:3])[NH2:2].[O:6]([CH:13]([CH3:17])[CH2:14][CH2:15][OH:16])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[S:1]([O:16][CH2:15][CH2:14][CH:13]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:17])(=[O:4])(=[O:3])[NH2:2]

Participants

3

Reactant 2

HCID 24499Chlorosulfamic acidHCID 15003276HCID 15003276, compound

Product 1

HCID 19108662HCID 19108662, compoundYield 67%

Procedure

The title compound was prepared by procedures of Example 33 from sulfamoyl chloride and 3-phenoxy-1-butanol. The viscous oil obtained was purified by high pressure chromatography using a Waters Associates Prep LC/System 500A; Prepak 500® silica and methylene chloride as eluting agent at a flow rate of 200 ml/min. Fractions containing the title compound were combined and the solvent was evaporated under reduced pressure to give 12.7 g (67%) of title compound as yellow, viscous oil.

Workup

  1. customThe viscous oil obtained
  2. customwas purified by high pressure chromatography
  3. washPrepak 500® silica and methylene chloride as eluting agent at a flow rate of 200 ml/min
  4. additionFractions containing the title compound
  5. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-52c7ed439617465db41aa92013d2c720
Source dataset
uspto-grants-1993_12
Patent number
US05273993

Reaction notes

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