反应详情

A mixture of 5.9 g (0.05 mole) of (S)-(+)methyl 3-hydroxy-2-methylpropionate, 9.5 g (0.055 mole) of phenyl sulfamate, 25 ml of toluene and 0.5 g of pyridine was heated at reflux for 2 hr. The reaction solution was concentrated under vacuum, and the residue was chromatographed, using silica gel and eluting with 2% methanol in methylene chloride. The desired fractions were concentrated under vacuum to give 3.9 g (40%) of a pale yellow oil.

1. temperaturewas heated
2. temperatureat reflux for 2 hr
3. concentrationThe reaction solution was concentrated under vacuum
4. customthe residue was chromatographed
5. washeluting with 2% methanol in methylene chloride
6. concentrationThe desired fractions were concentrated under vacuum