HCID 19733713, compound → HCID 11809022, compound

Participants

Reaction Steps

20 g of Raney nickel catalyst are added to a solution of 196 g of 2-(4-(5-chloro-3-nitropyridin-2-yloxy)phenoxy)propionic acid in 615 g of dioxane, and hydrogenation is subsequently carried out at 20°-22° C. under normal pressure. After separating the catalyst the solvent is removed, giving 98 g of 2-(4-(5-chloro-3-aminopyridin-2-yloxy)phenoxy)propionic acid as crude product (55% of theory) which has a melting point of 152°-154° C. and can be recrystallised from toluene.

Provenance & Evidence