反应详情

Using the procedure of example 4, [2-[5-[3,4-dihydro-4-oxo-8-propyl-2H-1-benzopyran-7-yl)oxy]pentyloxy]phenoxy]acetic acid was prepared in 72.3% overall yield starting from 0.31 g (1.5 mmol) of 2,3-dihydro-7-hydroxy-8-propyl-4H-1-benzopyran-4-one and 0.53 g (1.6 mmol) of [2-[(5-bromopentyl)oxy]phenoxy]acetic acid methyl ester, as a colorless solid, mp 98°-99° C., recrystallized from hexane-ethyl acetate.

1. customwas prepared in 72.3%
2. customoverall yield
3. customrecrystallized from hexane-ethyl acetate