1,4-Dibromobutane → 2-(4-Bromobutoxy)-5-[[3-(ethoxycarbonyl)phenyl]carbonyl]benzenepropanoic Acid Ethyl Ester

HRID 327948Notes

Reaction equation

HRID 327948 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[CH2:5][CH2:6][C:7]1[CH:12]=[C:11]([C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:16]=2)=[O:14])[CH:10]=[CH:9][C:8]=1[OH:26])[CH3:2].[Br:28][CH2:29][CH2:30][CH2:31][CH2:32]Br>>[CH2:1]([O:3][C:4](=[O:27])[CH2:5][CH2:6][C:7]1[CH:12]=[C:11]([C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:16]=2)=[O:14])[CH:10]=[CH:9][C:8]=1[O:26][CH2:32][CH2:31][CH2:30][CH2:29][Br:28])[CH3:2]

Participants

3

Reactant 2

HCID 80561,4-DibromobutaneHCID 147396575-[3-(Ethoxycarbonyl)benzoyl]-2-hydroxybenzenepropanoic acid ethyl ester

Product 1

HCID 537298942-(4-Bromobutoxy)-5-[[3-(ethoxycarbonyl)phenyl]carbonyl]benzenepropanoic Acid Ethyl EsterYield 81.2%

Procedure

Starting with 0.388 g (1.05 mmol) of 5-[[3-(ethoxycarbonyl)phenyl]carbonyl]-2-hydroxybenzenepropanoic acid ethyl ester, and 1.81 g (8.38 mmol) of 1,4-dibromobutane, the title compound was obtained as a colorless oil, in 81.2% yield, using the procedure of example 21.

Sources & evidence

ORD record
ord-52411dddab32432197c4ecb04bdf0eab
Source dataset
uspto-grants-1993_12
Patent number
US05273999

Reaction notes

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