HCID 67780412, compound → HCID 53826226, compound

Participants

Reaction Steps

A 2.0 g (5.26 mmol) sample of (E)-4-[3-[(5-hydroxypentyl)oxy]-4-(3-methoxy-3-oxo-1-propenyl)phenoxy]butanoic acid methyl ester was hydrogenated in 100 mL of 1:1 methanol-ethyl acetate, over 0.1 g of 10% palladium on carbon, at room temperature and 1 atmosphere. 2-[(5-Hydroxypentyl)oxy]-4-(4-methoxy-4-oxobutoxy)benzenepropanoic acid methyl ester, an oil, was isolated by filtration of the catalyst and concentration of the filtrate, in quantitative yield.

Provenance & Evidence