HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 6-bromohexanoate → rac-(E)-6-[2-(3-Methoxy-3-oxo-1-propenyl)-3-[6-[(tetrahydro-2H-pyran-2-yl)oxy]-1-hexynyl]phenoxy]hexanoic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 6-bromohexanoate | HCID 117544 | — |
| Reactant | rac-(E)-3-[2-hydroxy-6-[6-[(tetrahydro-2H-pyran-2-yl)oxy]-1-hexynyl]phenyl]-2-propenoic acid methyl ester | HCID 67694793 | — |
| Product | rac-(E)-6-[2-(3-Methoxy-3-oxo-1-propenyl)-3-[6-[(tetrahydro-2H-pyran-2-yl)oxy]-1-hexynyl]phenoxy]hexanoic Acid Ethyl Ester | HCID 67780093 | 93.3% |
Reaction Steps
Using the procedure of example 122, rac-(E)-3-[2-hydroxy-6-[6-[(tetrahydro-2H-pyran-2-yl)oxy]-1-hexynyl]phenyl]-2-propenoic acid methyl ester (example 121), was alkylated with ethyl 6-bromohexanoate giving the title compound as a pale-yellow oil, in 93.3% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05273999 |
| Source dataset | uspto-grants-1993_12 |
| ORD ID | ord-dd4343bb7e9e4be2810d918461c33098 |
| Source note | uspto-grants-1993_12 |