反应详情

To a stirred mixture of thiourea (8.87 g, 115 mmol) in ethanol (20.9 mL) was added 1-chloro-2,3-butanedione (13.90 g, 115 mmol) dropwise, a slight exothermic reaction resulted. The mixture was stirred at ambient temperature for 1 hour. The reaction mixture was filtered and the precipitate washed with ethyl ether (2×). The tan solid was air dried then dried under high vacuum overnight to give 1-(2-amino-thiazol-4-yl)-ethanone hydrochloride as a tan solid (21.5 g, 97%).

1. customa slight exothermic reaction
2. customresulted
3. filtrationThe reaction mixture was filtered
4. washthe precipitate washed with ethyl ether (2×)
5. customdried
6. customthen dried under high vacuum overnight