Benzylamine → HCID 54001745, compound

HRID 328095Notes

Reaction equation

C(N)C1C=CC=CC=1.C(OC([NH:19][C@H:20]([C:24]([NH:26][C@H:27]([C:29]([NH:31][C@H:32]([P:34](=[O:37])([OH:36])[OH:35])[CH3:33])=[O:30])[CH3:28])=[O:25])[CH:21]([CH3:23])[CH3:22])=O)C1C=CC=CC=1>>[NH2:19][C@H:20]([C:24]([NH:26][C@H:27]([C:29]([NH:31][C@H:32]([P:34](=[O:35])([OH:37])[OH:36])[CH3:33])=[O:30])[CH3:28])=[O:25])[CH:21]([CH3:23])[CH3:22]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 54008891HCID 54008891, compound

Product 1

HCID 54001745HCID 54001745, compound

Procedure

In a manner analogous to that given in Example 35 (b), from the benzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-L-valyl-L-alanyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(L-valyl-L-alanylamino)-ethylphosphonic acid of melting point 263°-265° C (decomposition); [α]D20 = -44.6° (c = 0.5% in water).

Sources & evidence

ORD record: ord-86a52858d66f4efa86e19b02abce4a5b
Source dataset: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04016148

Reaction notes

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