Chloroacetone → 7-nitro-2-[(2-chloro-1-methylethylidene)-hydrazino]-5-phenyl-3H-1,4-benzodiazepine

HRID 328103Notes

Reaction equation

HRID 328103 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]=[C:12]([NH:14][NH2:15])[CH2:11][N:10]=[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:8]=2[CH:22]=1)([O-:3])=[O:2].[Cl:23][CH2:24][C:25](=O)[CH3:26]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]=[C:12]([NH:14][N:15]=[C:25]([CH3:26])[CH2:24][Cl:23])[CH2:11][N:10]=[C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:8]=2[CH:22]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 22768399HCID 22768399, compound

Product 1

HCID 542793207-nitro-2-[(2-chloro-1-methylethylidene)-hydrazino]-5-phenyl-3H-1,4-benzodiazepine

Procedure

In the manner given in Example 1, 7-nitro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine can be reacted with chloropropanone to give 7-nitro-2-[(2-chloro-1-methylethylidene)-hydrazino]-5-phenyl-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-b695e467571847c6bd8067b64b1427ad
Source dataset
uspto-grants-1977_04
Patent number
US04016165

Reaction notes

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