HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 21443926, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(4-carbamimidoylphenyl)acetic Acid | HCID 10313357 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 21443926 | HCID 21443926 | 98.6% |
Reaction Steps
5.35 g of 4-amidinophenylacetic acid (M.p. 295° to 297° C, decomposition) were suspended in 45 ml of anhydrous benzene. Two drops of dimethylformamide and 17.9 g of thionyl chloride were added and the whole was heated for 11/2 hours under reflux. After cooling, the solid product was filtered off with suction, washed with anhydrous benzene and dried under reduced pressure. 6.9 g of 4-amidino-phenylacetyl chloride-hydrochloride melting at 174° to 177° C (decomposition) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04016159 |
| Source dataset | uspto-grants-1977_04 |
| ORD ID | ord-d93d65c20ae7453291def8277cf8f509 |
| Source note | uspto-grants-1977_04 |