Tetrahydrofuran → HCID 12812379, compound

Participants

Reaction Steps

To a solution of 3.0 g of 2-(m-nitroanilino)-N-propylbenzamide and 50 ml of tetrahydrofuran were added 1.1 g of 50 % sodium hydride and 4.9 g of 1,1' -carbonyldiimidazole. The mixture was stirred for one hour at room temperature and then refluxed for 5 hours. After the reaction was finished, the solvent was distilled off from the resulting mixture under reduced pressure, and to the residue obtained was added water to yield a precipitate. This product was recrystallized from methanol to yield 2.6 g of 1-(m-nitrophenyl)-3 -propylquinazoline-2,4(1H, 3H)-dione as colorless prisms, melting at 162°-163° C.

Provenance & Evidence