Water → HCID 12812387, compound

Participants

Reaction Steps

3.3 g of 2-(m-nitroanilino)-N-(2-ethoxyethyl)benzamide was dissolved in 30 ml of dry tetrahydrofuran, and to the solution was added 1.0 g of approximately 50 % sodium hydride. After stirring the mixture for 30 minutes, 3.2 g of N,N-dimethylcarbamoyl chloride was further added dropwise under cooling, and the whole was refluxed for 4 hours. After the reaction was complete, the solvent was evaporated from the resulting mixture under reduced pressure. To the residue thus obtained was added water to yield a crude product. This product was recrystallized from ethanol to give 3.1 g of 1-(m-nitrophenyl)-3-(2-ethoxyethyl)quinazoline-2,4(1H, 3H)-dione as pale yellow prisms, melting at 161°-162° C.

Provenance & Evidence