Benzene → HCID 70637798, compound

HRID 328135Notes

Reaction equation

HRID 328135 reaction equation
O=[C:2]1[CH2:20][CH2:19][N:5]2[C:6]3[CH:18]=[CH:17][CH:16]=[CH:15][C:7]=3[CH2:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH:4]2[CH2:3]1.C1C=CC=CC=1.[C:27](#[N:29])[CH3:28]>>[C:27]([CH:28]=[C:2]1[CH2:20][CH2:19][N:5]2[C:6]3[CH:18]=[CH:17][CH:16]=[CH:15][C:7]=3[CH2:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH:4]2[CH2:3]1)#[N:29]

Participants

4

Reactant 3

HCID 241BenzeneHCID 6342AcetonitrileHCID 70637887HCID 70637887, compound

Product 1

HCID 70637798HCID 70637798, compound

Procedure

1 g of 2-keto-1,2,3,4,10,14b-hexahydro-pyridino[1,2-a]-dibenzo[c,f]-azepine is mixed with 1 ml of benzene, 0.5 ml of acetonitril and 0.5 g of molecular sieve (4 A). 50 mg of sodium-ethoxyde are added and the mixture is heated for 3 hours (90°-100° C). After cooling the mixture the molecular sieve is filtered off and the filtrate evaporated. The precipitate is recrystallized from ethanol.

Workup

  1. temperaturethe mixture is heated for 3 hours (90°-100° C)
  2. temperatureAfter cooling the mixture the molecular sieve
  3. filtrationis filtered off
  4. customthe filtrate evaporated
  5. customThe precipitate is recrystallized from ethanol

Sources & evidence

ORD record
ord-8ae930408848436192f2be9628134088
Source dataset
uspto-grants-1977_04
Patent number
US04016161

Reaction notes

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