反应详情

In a mixture of 8ml of nitric acid and 15ml of acetic acid 1g of 2-(4-hydroxyphenyl)propionic acid was added and stirred at -10° to -20° C for 4 hours. The reaction mixture was poured into ice water and extracted with chloroform. The extract was washed with a sodium hydrogen carbonate solution and water and then dried over magnesium sulfate. The chloroform solution was concentrated to give crystals, which were recrystallized from water. Yield, 700 mg (58%).

1. additionwas added
2. extractionextracted with chloroform
3. washThe extract was washed with a sodium hydrogen carbonate solution and water
4. dry with materialdried over magnesium sulfate
5. concentrationThe chloroform solution was concentrated
6. customto give crystals, which
7. customwere recrystallized from water
8. customYield